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» Functional topology in a network of protein interactions
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BMCBI
2010
126views more  BMCBI 2010»
13 years 5 months ago
PETALS: Proteomic Evaluation and Topological Analysis of a mutated Locus' Signaling
Background: Colon cancer is driven by mutations in a number of genes, the most notorious of which is Apc. Though much of Apc's signaling has been mechanistically identified o...
Gürkan Bebek, Vishal Patel, Mark R. Chance
BMCBI
2008
95views more  BMCBI 2008»
13 years 7 months ago
Mining protein networks for synthetic genetic interactions
Background: The local connectivity and global position of a protein in a protein interaction network are known to correlate with some of its functional properties, including its e...
Sri R. Paladugu, Shan Zhao, Animesh Ray, Alpan Rav...
ICDM
2009
IEEE
152views Data Mining» more  ICDM 2009»
14 years 2 months ago
SLIDER: Mining Correlated Motifs in Protein-Protein Interaction Networks
Correlated motif mining (CMM) is the problem to find overrepresented pairs of patterns, called motif pairs, in interacting protein sequences. Algorithmic solutions for CMM thereb...
Peter Boyen, Frank Neven, Dries Van Dyck, Aalt-Jan...
COMPLIFE
2005
Springer
14 years 1 months ago
The Architecture of a Proteomic Network in the Yeast
Abstract. We describe an approach to clustering the yeast protein-protein interaction network in order to identify functional modules, groups of proteins forming multi-protein comp...
Emad Ramadan, Christopher Osgood, Alex Pothen
BMCBI
2007
114views more  BMCBI 2007»
13 years 7 months ago
Probabilistic prediction and ranking of human protein-protein interactions
Background: Although the prediction of protein-protein interactions has been extensively investigated for yeast, few such datasets exist for the far larger proteome in human. Furt...
Michelle S. Scott, Geoffrey J. Barton