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BMCBI
2011
12 years 11 months ago
Robust joint analysis allowing for model uncertainty in two-stage genetic association studies
Background: The cost efficient two-stage design is often used in genome-wide association studies (GWASs) in searching for genetic loci underlying the susceptibility for complex di...
Dongdong Pan, Qizhai Li, Ningning Jiang, Aiyi Liu,...
AAAI
1998
13 years 9 months ago
An Architecture for Exploring Large Design Spaces
We describe an architecture for exploring very large design spaces, for example, spaces that arise when design candidates are generated by combining components systematically from...
John R. Josephson, B. Chandrasekaran, Mark Carroll...
CEC
2010
IEEE
13 years 8 months ago
A novel memetic algorithm for constrained optimization
In this paper, we present a memetic algorithm with novel local optimizer hybridization strategy for constrained optimization. The developed MA consists of multiple cycles. In each ...
Jianyong Sun, Jonathan M. Garibaldi
BMCBI
2008
123views more  BMCBI 2008»
13 years 7 months ago
Validation of protein models by a neural network approach
Background: The development and improvement of reliable computational methods designed to evaluate the quality of protein models is relevant in the context of protein structure re...
Paolo Mereghetti, Maria Luisa Ganadu, Elena Papale...
BMCBI
2011
12 years 11 months ago
Improving pan-genome annotation using whole genome multiple alignment
Background: Rapid annotation and comparisons of genomes from multiple isolates (pan-genomes) is becoming commonplace due to advances in sequencing technology. Genome annotations c...
Samuel V. Angiuoli, Julie C. Dunning Hotopp, Steve...