Background: Several problems exist with current methods used to align DNA sequences for comparative sequence analysis. Most dynamic programming algorithms assume that conserved se...
In the initial stage of sequence analysis, a biologist is first faced with the questions about how to choose the best tool to align sequences of interest and how to analyze and v...
Arthur Chun-Chieh Shih, D. T. Lee, Laurent Lin, Ch...
Evaluating the accuracy of multiple sequence alignment (MSA) is critical for virtually every comparative sequence analysis that uses an MSA as input. Here we present the GUIDANCE ...
Background: The recent accumulation of closely related genomic sequences provides a valuable resource for the elucidation of the evolutionary histories of various organisms. Howev...
Background: Comparing related structures and viewing the structures in the context of sequence alignments are important tasks in protein structure-function research. While many pr...
Elaine C. Meng, Eric F. Pettersen, Gregory S. Couc...