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» GOGOT: a method for the identification of differentially exp...
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BMCBI
2010
135views more  BMCBI 2010»
13 years 7 months ago
Delineation of amplification, hybridization and location effects in microarray data yields better-quality normalization
Background: Oligonucleotide arrays have become one of the most widely used high-throughput tools in biology. Due to their sensitivity to experimental conditions, normalization is ...
Marc Hulsman, Anouk Mentink, Eugene P. van Someren...
BMCBI
2007
105views more  BMCBI 2007»
13 years 7 months ago
Extended analysis of benchmark datasets for Agilent two-color microarrays
Background: As part of its broad and ambitious mission, the MicroArray Quality Control (MAQC) project reported the results of experiments using External RNA Controls (ERCs) on fiv...
Kathleen F. Kerr
BMCBI
2008
147views more  BMCBI 2008»
13 years 7 months ago
Simple integrative preprocessing preserves what is shared in data sources
Background: Bioinformatics data analysis toolbox needs general-purpose, fast and easily interpretable preprocessing tools that perform data integration during exploratory data ana...
Abhishek Tripathi, Arto Klami, Samuel Kaski
BMCBI
2007
86views more  BMCBI 2007»
13 years 7 months ago
Toxicogenomic analysis incorporating operon-transcriptional coupling and toxicant concentration-expression response: analysis of
Background: Deficiencies in microarray technology cause unwanted variation in the hybridization signal, obscuring the true measurements of intracellular transcript levels. Here we...
William O. Ward, Carol D. Swartz, Steffen Porwolli...
BMCBI
2010
129views more  BMCBI 2010»
13 years 7 months ago
Geoseq: a tool for dissecting deep-sequencing datasets
Background: Datasets generated on deep-sequencing platforms have been deposited in various public repositories such as the Gene Expression Omnibus (GEO), Sequence Read Archive (SR...
James Gurtowski, Anthony Cancio, Hardik Shah, Chay...