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BMCBI
2007
121views more  BMCBI 2007»
13 years 7 months ago
A constrained polynomial regression procedure for estimating the local False Discovery Rate
Background: In the context of genomic association studies, for which a large number of statistical tests are performed simultaneously, the local False Discovery Rate (lFDR), which...
Cyril Dalmasso, Avner Bar-Hen, Philippe Broët
BMCBI
2010
153views more  BMCBI 2010»
13 years 6 months ago
DiffCoEx: a simple and sensitive method to find differentially coexpressed gene modules
Background: Large microarray datasets have enabled gene regulation to be studied through coexpression analysis. While numerous methods have been developed for identifying differen...
Bruno M. Tesson, Rainer Breitling, Ritsert C. Jans...
NAR
2007
135views more  NAR 2007»
13 years 7 months ago
g: Profiler - a web-based toolset for functional profiling of gene lists from large-scale experiments
g:Profiler (http://biit.cs.ut.ee/gprofiler/) is a public web server for characterising and manipulating gene lists resulting from mining high-throughput genomic data. g:Profiler h...
Jüri Reimand, Meelis Kull, Hedi Peterson, Jaa...
BIOCOMP
2008
13 years 9 months ago
Reverse Engineering Module Networks by PSO-RNN Hybrid Modeling
Background: Inferring a gene regulatory network (GRN) from high throughput biological data is often an under-determined problem and is a challenging task due to the following reas...
Yuji Zhang, Jianhua Xuan, Benildo de los Reyes, Ro...
BIBM
2009
IEEE
155views Bioinformatics» more  BIBM 2009»
14 years 2 months ago
Towards Reliable Isoform Quantification Using RNA-Seq Data
Background: In eukaryotes, alternative splicing often generates multiple splice variants from a single gene. Here weexplore the use of RNA sequencing (RNA-Seq) datasets to address...
Brian E. Howard, Steffen Heber