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» Gene finding in novel genomes
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BMCBI
2011
12 years 11 months ago
Wavelet-based identification of DNA focal genomic aberrations from single nucleotide polymorphism arrays
Background: Copy number aberrations (CNAs) are an important molecular signature in cancer initiation, development, and progression. However, these aberrations span a wide range of...
Youngmi Hur, Hyunju Lee
BMCBI
2010
101views more  BMCBI 2010»
13 years 8 months ago
Enrichment of homologs in insignificant BLAST hits by co-complex network alignment
Background: Homology is a crucial concept in comparative genomics. The algorithm probably most widely used for homology detection in comparative genomics, is BLAST. Usually a stri...
Like Fokkens, Sandra M. C. Botelho, Jos Boekhorst,...
BMCBI
2010
135views more  BMCBI 2010»
13 years 8 months ago
Efficient genome-scale phylogenetic analysis under the duplication-loss and deep coalescence cost models
Background: Genomic data provide a wealth of new information for phylogenetic analysis. Yet making use of this data requires phylogenetic methods that can efficiently analyze extr...
Mukul S. Bansal, J. Gordon Burleigh, Oliver Eulens...
CSB
2002
IEEE
117views Bioinformatics» more  CSB 2002»
14 years 1 months ago
A Literature Based Method for Identifying Gene-Disease Connections
We present a statistical method that can swiftly identify, from the literature, sets of genes known to be associated with given diseases. It offers a comprehensive way to treat al...
Lada A. Adamic, Dennis M. Wilkinson, Bernardo A. H...
RECOMB
2006
Springer
14 years 8 months ago
A Parsimony Approach to Genome-Wide Ortholog Assignment
The assignment of orthologous genes between a pair of genomes is a fundamental and challenging problem in comparative genomics, since many computational methods for solving various...
Zheng Fu, Xin Chen, Vladimir Vacic, Peng Nan, Yang...