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» Gene finding in novel genomes
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WEA
2005
Springer
176views Algorithms» more  WEA 2005»
14 years 1 months ago
High-Performance Algorithm Engineering for Large-Scale Graph Problems and Computational Biology
Abstract. Many large-scale optimization problems rely on graph theoretic solutions; yet high-performance computing has traditionally focused on regular applications with high degre...
David A. Bader
BMCBI
2007
175views more  BMCBI 2007»
13 years 8 months ago
Fast automated cell phenotype image classification
Background: The genomic revolution has led to rapid growth in sequencing of genes and proteins, and attention is now turning to the function of the encoded proteins. In this respe...
Nicholas A. Hamilton, Radosav S. Pantelic, Kelly H...
BMCBI
2008
84views more  BMCBI 2008»
13 years 8 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....
BMCBI
2007
142views more  BMCBI 2007»
13 years 8 months ago
LinkHub: a Semantic Web system that facilitates cross-database queries and information retrieval in proteomics
nd: A key abstraction in representing proteomics knowledge is the notion of unique identifiers for individual entities (e.g. proteins) and the massive graph of relationships among...
Andrew K. Smith, Kei-Hoi Cheung, Kevin Y. Yip, Mar...
ALMOB
2006
155views more  ALMOB 2006»
13 years 8 months ago
Refining motifs by improving information content scores using neighborhood profile search
The main goal of the motif finding problem is to detect novel, over-represented unknown signals in a set of sequences (e.g. transcription factor binding sites in a genome). The mo...
Chandan K. Reddy, Yao-Chung Weng, Hsiao-Dong Chian...