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» Gene set analysis using principal components
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BMCBI
2005
80views more  BMCBI 2005»
13 years 9 months ago
Sample phenotype clusters in high-density oligonucleotide microarray data sets are revealed using Isomap, a nonlinear algorithm
Background: Life processes are determined by the organism's genetic profile and multiple environmental variables. However the interaction between these factors is inherently ...
Kevin Dawson, Raymond L. Rodriguez, Wasyl Malyj
WABI
2001
Springer
162views Bioinformatics» more  WABI 2001»
14 years 2 months ago
A Simple Hyper-Geometric Approach for Discovering Putative Transcription Factor Binding Sites
A central issue in molecular biology is understanding the regulatory mechanisms that control gene expression. The recent flood of genomic and postgenomic data opens the way for co...
Yoseph Barash, Gill Bejerano, Nir Friedman
BMCBI
2007
151views more  BMCBI 2007»
13 years 9 months ago
A statistical method to incorporate biological knowledge for generating testable novel gene regulatory interactions from microar
Background: The incorporation of prior biological knowledge in the analysis of microarray data has become important in the reconstruction of transcription regulatory networks in a...
Peter Larsen, Eyad Almasri, Guanrao Chen, Yang Dai
GFKL
2005
Springer
141views Data Mining» more  GFKL 2005»
14 years 3 months ago
On External Indices for Mixtures: Validating Mixtures of Genes
Mixture models represent results of gene expression cluster analysis in a more natural way than ’hard’ partitions. This is also true for the representation of gene labels, such...
Ivan G. Costa, Alexander Schliep
BMCBI
2007
123views more  BMCBI 2007»
13 years 9 months ago
GO for gene documents
Annotating genes and their products with Gene Ontology codes is an important area of research. One approach for doing this is to use the information available about these genes in...
Padmini Srinivasan, Xin Ying Qiu