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BMCBI
2010
96views more  BMCBI 2010»
13 years 7 months ago
A statistical framework for differential network analysis from microarray data
Background: It has been long well known that genes do not act alone; rather groups of genes act in consort during a biological process. Consequently, the expression levels of gene...
Ryan Gill, Somnath Datta, Susmita Datta
BMCBI
2007
161views more  BMCBI 2007»
13 years 7 months ago
Efficient classification of complete parameter regions based on semidefinite programming
Background: Current approaches to parameter estimation are often inappropriate or inconvenient for the modelling of complex biological systems. For systems described by nonlinear ...
Lars Kuepfer, Uwe Sauer, Pablo A. Parrilo
BMCBI
2006
239views more  BMCBI 2006»
13 years 7 months ago
Applying dynamic Bayesian networks to perturbed gene expression data
Background: A central goal of molecular biology is to understand the regulatory mechanisms of gene transcription and protein synthesis. Because of their solid basis in statistics,...
Norbert Dojer, Anna Gambin, Andrzej Mizera, Bartek...
BMCBI
2006
175views more  BMCBI 2006»
13 years 7 months ago
Parameter estimation for stiff equations of biosystems using radial basis function networks
Background: The modeling of dynamic systems requires estimating kinetic parameters from experimentally measured time-courses. Conventional global optimization methods used for par...
Yoshiya Matsubara, Shinichi Kikuchi, Masahiro Sugi...
BMCBI
2006
124views more  BMCBI 2006»
13 years 7 months ago
Detection of divergent genes in microbial aCGH experiments
Background: Array-based comparative genome hybridization (aCGH) is a tool for rapid comparison of genomes from different bacterial strains. The purpose of such analysis is to dete...
Lars Snipen, Dirk Repsilber, Ludvig Nyquist, &Arin...