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» Genome Sequence Assembly: Algorithms and Issues
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METMBS
2004
162views Mathematics» more  METMBS 2004»
13 years 10 months ago
A Comparison of DNA Fragment Assembly Algorithms
As more research centers embark on sequencing new genomes, the problem of DNA fragment assembly for shotgun sequencing is growing in importance and complexity. Accurate and fast a...
Lishan Li, Sami Khuri
GCB
2004
Springer
92views Biometrics» more  GCB 2004»
14 years 1 months ago
Syntenic Layout of Two Assemblies of Related Genomes
: To facilitate research in comparative genomics, sequencing projects are increasingly aimed at assembling the genomes of closely related organisms. Given two incomplete assemblies...
Olaf Delgado Friedrichs, Aaron L. Halpern, Ross Li...
RECOMB
2008
Springer
14 years 8 months ago
Ab Initio Whole Genome Shotgun Assembly with Mated Short Reads
Next Generation Sequencing (NGS) technologies are capable of reading millions of short DNA sequences both quickly and cheaply. While these technologies are already being used for r...
Paul Medvedev, Michael Brudno
GCB
2010
Springer
182views Biometrics» more  GCB 2010»
13 years 6 months ago
Repeat-aware Comparative Genome Assembly
: The current high-throughput sequencing technologies produce gigabytes of data even when prokaryotic genomes are processed. In a subsequent assembly phase, the generated overlappi...
Peter Husemann, Jens Stoye
BMCBI
2010
161views more  BMCBI 2010»
13 years 6 months ago
LTC: a novel algorithm to improve the efficiency of contig assembly for physical mapping in complex genomes
Background: Physical maps are the substrate of genome sequencing and map-based cloning and their construction relies on the accurate assembly of BAC clones into large contigs that...
Zeev Frenkel, Etienne Paux, David I. Mester, Cathe...