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BMCBI
2007
130views more  BMCBI 2007»
13 years 7 months ago
A model-based optimization framework for the inference of regulatory interactions using time-course DNA microarray expression da
Background: Proteins are the primary regulatory agents of transcription even though mRNA expression data alone, from systems like DNA microarrays, are widely used. In addition, th...
Reuben Thomas, Carlos J. Paredes, Sanjay Mehrotra,...
CEC
2009
IEEE
14 years 10 days ago
Conformity and network effects in the Prisoner's Dilemma
— We study the evolution of cooperation using the Prisoner’s Dilemma as a metaphor of the tensions between cooperators and non-cooperators, and evolutionary game theory as the ...
José María Peña, Enea Pestela...
BMCBI
2010
138views more  BMCBI 2010»
13 years 7 months ago
A model-independent approach to infer hierarchical codon substitution dynamics
Background: Codon substitution constitutes a fundamental process in molecular biology that has been studied extensively. However, prior studies rely on various assumptions, e.g. r...
Olof Görnerup, Martin Nilsson Jacobi
GECCO
2006
Springer
202views Optimization» more  GECCO 2006»
13 years 11 months ago
Inference of genetic networks using S-system: information criteria for model selection
In this paper we present an evolutionary approach for inferring the structure and dynamics in gene circuits from observed expression kinetics. For representing the regulatory inte...
Nasimul Noman, Hitoshi Iba
ISCA
2007
IEEE
196views Hardware» more  ISCA 2007»
14 years 1 months ago
Anton, a special-purpose machine for molecular dynamics simulation
The ability to perform long, accurate molecular dynamics (MD) simulations involving proteins and other biological macromolecules could in principle provide answers to some of the ...
David E. Shaw, Martin M. Deneroff, Ron O. Dror, Je...