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BMCBI
2006
126views more  BMCBI 2006»
13 years 7 months ago
Effect of data normalization on fuzzy clustering of DNA microarray data
Background: Microarray technology has made it possible to simultaneously measure the expression levels of large numbers of genes in a short time. Gene expression data is informati...
Seo Young Kim, Jae Won Lee, Jong Sung Bae
BMCBI
2008
186views more  BMCBI 2008»
13 years 7 months ago
Variable selection for large p small n regression models with incomplete data: Mapping QTL with epistases
Background: Identifying quantitative trait loci (QTL) for both additive and epistatic effects raises the statistical issue of selecting variables from a large number of candidates...
Min Zhang, Dabao Zhang, Martin T. Wells
ECAL
2005
Springer
14 years 1 months ago
CelloS: A Multi-level Approach to Evolutionary Dynamics
We study the evolution of simple cells that are equipped with a genome, a rudimentary gene regulation network at transcription level and two classes of functional genes: motion eï¬...
Camille Stephan-Otto Attolini, Peter F. Stadler, C...
CIBCB
2005
IEEE
14 years 1 months ago
Two-Phase EA/k-NN for Feature Selection and Classification in Cancer Microarray Datasets
Efficient and reliable methods that can find a small sample of informative genes amongst thousands are of great importance. In this area, much research is investigating the combina...
Thorhildur Juliusdottir, David Corne, Ed Keedwell,...
BMCBI
2008
84views more  BMCBI 2008»
13 years 7 months ago
Prediction of specificity-determining residues for small-molecule kinase inhibitors
Background: Designing small-molecule kinase inhibitors with desirable selectivity profiles is a major challenge in drug discovery. A high-throughput screen for inhibitors of a giv...
Daniel R. Caffrey, Elizabeth A. Lunney, Deborah J....