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BMCBI
2007
111views more  BMCBI 2007»
13 years 7 months ago
MotifCombinator: a web-based tool to search for combinations of cis-regulatory motifs
Background: A combination of multiple types of transcription factors and cis-regulatory elements is often required for gene expression in eukaryotes, and the combinatorial regulat...
Mamoru Kato, Tatsuhiko Tsunoda
BMCBI
2006
116views more  BMCBI 2006»
13 years 7 months ago
Optimized mixed Markov models for motif identification
Background: Identifying functional elements, such as transcriptional factor binding sites, is a fundamental step in reconstructing gene regulatory networks and remains a challengi...
Weichun Huang, David M. Umbach, Uwe Ohler, Leping ...
TREC
2003
13 years 8 months ago
Report on the TREC 2003 Experiment: Genomic Track
After retrieval, this simple strategy yield to an important improvement of the average precision: from 17.02 up to 35.80. Task II. Our approach is based on argumentative structurin...
Patrick Ruch, Gilles Cohen, Frédéric...
BMCBI
2007
114views more  BMCBI 2007»
13 years 7 months ago
Large scale statistical inference of signaling pathways from RNAi and microarray data
Background: The advent of RNA interference techniques enables the selective silencing of biologically interesting genes in an efficient way. In combination with DNA microarray tec...
Holger Fröhlich, Mark Fellmann, Holger Sü...
BMCBI
2007
120views more  BMCBI 2007»
13 years 7 months ago
Re-sampling strategy to improve the estimation of number of null hypotheses in FDR control under strong correlation structures
Background: When conducting multiple hypothesis tests, it is important to control the number of false positives, or the False Discovery Rate (FDR). However, there is a tradeoff be...
Xin Lu, David L. Perkins