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BMCBI
2006
122views more  BMCBI 2006»
13 years 7 months ago
A multivariate prediction model for microarray cross-hybridization
Background: Expression microarray analysis is one of the most popular molecular diagnostic techniques in the post-genomic era. However, this technique faces the fundamental proble...
Yian A. Chen, Cheng-Chung Chou, Xinghua Lu, Elizab...
BMCBI
2007
96views more  BMCBI 2007»
13 years 7 months ago
Features generated for computational splice-site prediction correspond to functional elements
Background: Accurate selection of splice sites during the splicing of precursors to messenger RNA requires both relatively well-characterized signals at the splice sites and auxil...
Rezarta Islamaj Dogan, Lise Getoor, W. John Wilbur...
BMCBI
2007
107views more  BMCBI 2007»
13 years 7 months ago
A computational approach for detecting peptidases and their specific inhibitors at the genome level
Background: Peptidases are proteolytic enzymes responsible for fundamental cellular activities in all organisms. Apparently about 2–5% of the genes encode for peptidases, irresp...
Lisa Bartoli, Remo Calabrese, Piero Fariselli, Dam...
BMCBI
2004
128views more  BMCBI 2004»
13 years 7 months ago
Comparing transformation methods for DNA microarray data
Background: When DNA microarray data are used for gene clustering, genotype/phenotype correlation studies, or tissue classification the signal intensities are usually transformed ...
Helene H. Thygesen, Aeilko H. Zwinderman
BMCBI
2006
82views more  BMCBI 2006»
13 years 7 months ago
Profiling alternatively spliced mRNA isoforms for prostate cancer classification
Background: Prostate cancer is one of the leading causes of cancer illness and death among men in the United States and world wide. There is an urgent need to discover good biomar...
Chaolin Zhang, Hai-Ri Li, Jian-Bing Fan, Jessica W...