Background: The PD-(D/E)XK nuclease superfamily, initially identified in type II restriction endonucleases and later in many enzymes involved in DNA recombination and repair, is o...
One of the major limitations of HMM-based models is the inability to cope with topology: When applied to a visible observation (VO) sequence, HMM-based techniques have difficulty ...
Background: The process of oxidative folding combines the formation of native disulfide bond with conformational folding resulting in the native three-dimensional fold. Oxidative ...
Motivation: Proteins of all kinds can self-assemble into highly ordered β-sheet aggregates known as amyloid fibrils, important both biologically and clinically. However, the spe...
Abstract—Docking simulates molecular interactions. Protein - protein docking, owing to the sizes of molecules, is a very challenging problem. As the number of degrees of freedom ...