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BMCBI
2010
146views more  BMCBI 2010»
13 years 8 months ago
A pairwise residue contact area-based mean force potential for discrimination of native protein structure
Background: Considering energy function to detect a correct protein fold from incorrect ones is very important for protein structure prediction and protein folding. Knowledge-base...
Shahriar Arab, Mehdi Sadeghi, Changiz Eslahchi, Ha...
BMCBI
2010
119views more  BMCBI 2010»
13 years 8 months ago
Multi-task learning for cross-platform siRNA efficacy prediction: an in-silico study
Background: Gene silencing using exogenous small interfering RNAs (siRNAs) is now a widespread molecular tool for gene functional study and new-drug target identification. The key...
Qi Liu, Qian Xu, Vincent Wenchen Zheng, Hong Xue, ...
BMCBI
2006
107views more  BMCBI 2006»
13 years 8 months ago
A reinforced merging methodology for mapping unique peptide motifs in members of protein families
Background: Members of a protein family often have highly conserved sequences; most of these sequences carry identical biological functions and possess similar three-dimensional (...
Hao-Teng Chang, Tun-Wen Pai, Tan-Chi Fan, Bo-Han S...
BIOINFORMATICS
2006
101views more  BIOINFORMATICS 2006»
13 years 8 months ago
A lock-and-key model for protein-protein interactions
Motivation: Protein-protein interaction networks are one of the major post-genomic data sources available to molecular biologists. They provide a comprehensive view of the global ...
Julie L. Morrison, Rainer Breitling, Desmond J. Hi...
BMCBI
2005
162views more  BMCBI 2005»
13 years 8 months ago
Accelerated probabilistic inference of RNA structure evolution
Background: Pairwise stochastic context-free grammars (Pair SCFGs) are powerful tools for evolutionary analysis of RNA, including simultaneous RNA sequence alignment and secondary...
Ian Holmes