34 search results - page 4 / 7 » High-throughput identification of interacting protein-protei... |
BMCBI
2010
13 years 7 months ago
2010
Background: Modelling the ligand binding site of a protein is an important component of understanding proteinligand interactions and is being actively studied. Even if the side ch...
BMCBI
2005
13 years 7 months ago
2005
Background: The PD-(D/E)XK nuclease superfamily, initially identified in type II restriction endonucleases and later in many enzymes involved in DNA recombination and repair, is o...
BMCBI
2010
13 years 2 months ago
2010
Background: Profile HMMs (hidden Markov models) provide effective methods for modeling the conserved regions of protein families. A limitation of the resulting domain models is th...
BMCBI
2010
13 years 7 months ago
2010
Background: Signal transduction events often involve transient, yet specific, interactions between structurally conserved protein domains and polypeptide sequences in target prote...
BMCBI
2010
13 years 7 months ago
2010
Background: Functional genomic studies involving high-throughput sequencing and tiling array applications, such as ChIP-seq and ChIP-chip, generate large numbers of experimentally...