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BMCBI
2010
13 years 11 months ago
2010
Background: Identifying disease gene from a list of candidate genes is an important task in bioinformatics. The main strategy is to prioritize candidate genes based on their simil...
BMCBI
2010
13 years 11 months ago
2010
Background: Codon substitution constitutes a fundamental process in molecular biology that has been studied extensively. However, prior studies rely on various assumptions, e.g. r...
BMCBI
2010
13 years 11 months ago
2010
Background: Biological processes in cells are carried out by means of protein-protein interactions. Determining whether a pair of proteins interacts by wet-lab experiments is reso...
BMCBI
2007
13 years 11 months ago
2007
Background: The genomic revolution has led to rapid growth in sequencing of genes and proteins, and attention is now turning to the function of the encoded proteins. In this respe...
BMCBI
2007
13 years 11 months ago
2007
Background: Cis-acting transcriptional regulatory elements in mammalian genomes typically contain specific combinations of binding sites for various transcription factors. Althoug...