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BIBE
2010
IEEE
143views Bioinformatics» more  BIBE 2010»
13 years 9 months ago
The Effect of Sequence Error and Partial Training Data on BLAST Accuracy
- Metagenomics is the study of environmental samples. Because few tools exist for metagenomic analysis, a natural step has been to utilize the popular homology tool, BLAST, to sear...
Steven D. Essinger, Gail L. Rosen
BMCBI
2010
163views more  BMCBI 2010»
13 years 8 months ago
Reduced representation of protein structure: implications on efficiency and scope of detection of structural similarity
Background: Computational comparison of two protein structures is the starting point of many methods that build on existing knowledge, such as structure modeling (including modeli...
Zong Hong Zhang, Hwee Kuan Lee, Ivana Mihalek
BMCBI
2010
137views more  BMCBI 2010»
13 years 8 months ago
Improving pairwise sequence alignment accuracy using near-optimal protein sequence alignments
Background: While the pairwise alignments produced by sequence similarity searches are a powerful tool for identifying homologous proteins - proteins that share a common ancestor ...
Michael L. Sierk, Michael E. Smoot, Ellen J. Bass,...
BMCBI
2007
132views more  BMCBI 2007»
13 years 8 months ago
TPRpred: a tool for prediction of TPR-, PPR- and SEL1-like repeats from protein sequences
Background: Solenoid repeat proteins of the Tetratrico Peptide Repeat (TPR) family are involved as scaffolds in a broad range of protein-protein interactions. Several resources ar...
Manjunatha R. Karpenahalli, Andrei N. Lupas, Johan...
BMCBI
2008
130views more  BMCBI 2008»
13 years 8 months ago
A novel series of compositionally biased substitution matrices for comparing Plasmodium proteins
Background: The most common substitution matrices currently used (BLOSUM and PAM) are based on protein sequences with average amino acid distributions, thus they do not represent ...
Kevin Brick, Elisabetta Pizzi