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    BMCBI
    2007
    114views more  BMCBI 2007»
    Large scale statistical inference of signaling pathways from RNAi and microarray data
    13 years 9 months ago
    Large scale statistical inference of signaling pathways from RNAi and microarray data
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    Background: The advent of RNA interference techniques enables the selective silencing of biologically interesting genes in an efficient way. In combination with DNA microarray tec...
    Holger Fröhlich, Mark Fellmann, Holger Sü...
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    BMCBI
    2008
    163views more  BMCBI 2008»
    Gene Ontology term overlap as a measure of gene functional similarity
    13 years 9 months ago
    Gene Ontology term overlap as a measure of gene functional similarity
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    Background: The availability of various high-throughput experimental and computational methods allows biologists to rapidly infer functional relationships between genes. It is oft...
    Meeta Mistry, Paul Pavlidis
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    BMCBI
    2010
    153views more  BMCBI 2010»
    Challenges in microarray class discovery: a comprehensive examination of normalization, gene selection and clustering
    13 years 9 months ago
    Challenges in microarray class discovery: a comprehensive examination of normalization, gene selection and clustering
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    Background: Cluster analysis, and in particular hierarchical clustering, is widely used to extract information from gene expression data. The aim is to discover new classes, or su...
    Eva Freyhult, Mattias Landfors, Jenny Önskog,...
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    BMCBI
    2007
    233views more  BMCBI 2007»
    160-fold acceleration of the Smith-Waterman algorithm using a field programmable gate array (FPGA)
    13 years 9 months ago
    160-fold acceleration of the Smith-Waterman algorithm using a field programmable gate array (FPGA)
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    Background: To infer homology and subsequently gene function, the Smith-Waterman (SW) algorithm is used to find the optimal local alignment between two sequences. When searching s...
    Isaac T. S. Li, Warren Shum, Kevin Truong
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    BMCBI
    2008
    108views more  BMCBI 2008»
    A nonparametric model for quality control of database search results in shotgun proteomics
    13 years 9 months ago
    A nonparametric model for quality control of database search results in shotgun proteomics
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    Background: Analysis of complex samples with tandem mass spectrometry (MS/MS) has become routine in proteomic research. However, validation of database search results creates a bo...
    Jiyang Zhang, Jianqi Li, Xin Liu, Hongwei Xie, Yun...
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