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» Identifying Structural Motifs in Proteins
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BMCBI
2006
75views more  BMCBI 2006»
13 years 10 months ago
A machine learning strategy to identify candidate binding sites in human protein-coding sequence
Background: The splicing of RNA transcripts is thought to be partly promoted and regulated by sequences embedded within exons. Known sequences include binding sites for SR protein...
Thomas Down, Bernard Leong, Tim J. P. Hubbard
WABI
2010
Springer
167views Bioinformatics» more  WABI 2010»
13 years 8 months ago
Quantifying the Strength of Natural Selection of a Motif Sequence
Quantification of selective pressures on regulatory sequences is a central question in studying the evolution of gene regulatory networks. Previous methods focus primarily on sing...
Chen-Hsiang Yeang
JCB
2006
215views more  JCB 2006»
13 years 9 months ago
Protein Fold Recognition Using Segmentation Conditional Random Fields (SCRFs)
Protein fold recognition is an important step towards understanding protein three-dimensional structures and their functions. A conditional graphical model, i.e., segmentation con...
Yan Liu 0002, Jaime G. Carbonell, Peter Weigele, V...
TCBB
2010
98views more  TCBB 2010»
13 years 4 months ago
VARUN: Discovering Extensible Motifs under Saturation Constraints
Abstract-The discovery of motifs in biosequences is frequently torn between the rigidity of the model on the one hand and the abundance of candidates on the other. In particular, m...
Alberto Apostolico, Matteo Comin, Laxmi Parida
NAR
2011
193views Computer Vision» more  NAR 2011»
13 years 20 days ago
AREsite: a database for the comprehensive investigation of AU-rich elements
AREsite is an online resource for the detailed investigation of AU-rich elements (ARE) in vertebrate mRNA 30 -untranslated regions (UTRs). AREs are one of the most prominent cis-a...
Andreas R. Gruber, Jörg Fallmann, Franz Krato...