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NIPS
2008
13 years 9 months ago
DiscLDA: Discriminative Learning for Dimensionality Reduction and Classification
Probabilistic topic models have become popular as methods for dimensionality reduction in collections of text documents or images. These models are usually treated as generative m...
Simon Lacoste-Julien, Fei Sha, Michael I. Jordan
BMCBI
2007
117views more  BMCBI 2007»
13 years 8 months ago
Supervised multivariate analysis of sequence groups to identify specificity determining residues
Background: Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper ...
Iain M. Wallace, Desmond G. Higgins
BMCBI
2010
95views more  BMCBI 2010»
13 years 8 months ago
Identifying main effects and epistatic interactions from large-scale SNP data via adaptive group Lasso
Background: Single nucleotide polymorphism (SNP) based association studies aim at identifying SNPs associated with phenotypes, for example, complex diseases. The associated SNPs m...
Can Yang, Xiang Wan, Qiang Yang, Hong Xue, Weichua...
BMCBI
2007
99views more  BMCBI 2007»
13 years 8 months ago
Identifying allosteric fluctuation transitions between different protein conformational states as applied to Cyclin Dependent Ki
Background: The mechanisms underlying protein function and associated conformational change are dominated by a series of local entropy fluctuations affecting the global structure ...
Jenny Gu, Philip E. Bourne
BMCBI
2007
133views more  BMCBI 2007»
13 years 8 months ago
Semantic integration to identify overlapping functional modules in protein interaction networks
Background: The systematic analysis of protein-protein interactions can enable a better understanding of cellular organization, processes and functions. Functional modules can be ...
Young-Rae Cho, Woochang Hwang, Murali Ramanathan, ...