Understanding the protein folding mechanism remains a grand challenge in structural biology. In the past several years, computational theories in molecular dynamics have been empl...
Background: Empirical scoring functions have proven useful in protein structure modeling. Most such scoring functions depend on protein side chain conformations. However, backbone...
Background: The accumulation of high-throughput data greatly promotes computational investigation of gene function in the context of complex biological systems. However, a biologi...
Background: Domains are the basic functional units of proteins. It is believed that protein-protein interactions are realized through domain interactions. Revealing multi-domain c...
Background: Network co-regulated modules are believed to have the functionality of packaging multiple biological entities, and can thus be assumed to coordinate many biological fu...
Lina Chen, Hong Wang, Liangcai Zhang, Wan Li, Qian...