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BMCBI
2010
105views more  BMCBI 2010»
15 years 4 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
JAIR
2008
119views more  JAIR 2008»
15 years 4 months ago
A Multiagent Reinforcement Learning Algorithm with Non-linear Dynamics
Several multiagent reinforcement learning (MARL) algorithms have been proposed to optimize agents' decisions. Due to the complexity of the problem, the majority of the previo...
Sherief Abdallah, Victor R. Lesser
PR
2008
88views more  PR 2008»
15 years 4 months ago
Modified global k
Clustering in gene expression data sets is a challenging problem. Different algorithms for clustering of genes have been proposed. However due to the large number of genes only a ...
Adil M. Bagirov
ICCAD
2008
IEEE
140views Hardware» more  ICCAD 2008»
16 years 1 months ago
Algorithms for simultaneous consideration of multiple physical synthesis transforms for timing closure
We propose a post-placement physical synthesis algorithm that can apply multiple circuit synthesis and placement transforms on a placed circuit to improve the critical path delay ...
Huan Ren, Shantanu Dutt
HIS
2003
15 years 5 months ago
PDGA: the Primal-Dual Genetic Algorithm
Abstract. Genetic algorithms (GAs) are a class of search algorithms based on principles of natural evolution. Hence, incorporating mechanisms used in nature may improve the perform...
Shengxiang Yang