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BMCBI
2008
186views more  BMCBI 2008»
13 years 7 months ago
Variable selection for large p small n regression models with incomplete data: Mapping QTL with epistases
Background: Identifying quantitative trait loci (QTL) for both additive and epistatic effects raises the statistical issue of selecting variables from a large number of candidates...
Min Zhang, Dabao Zhang, Martin T. Wells
BMCBI
2010
122views more  BMCBI 2010»
13 years 7 months ago
Fast and accurate protein substructure searching with simulated annealing and GPUs
Background: Searching a database of protein structures for matches to a query structure, or occurrences of a structural motif, is an important task in structural biology and bioin...
Alex Stivala, Peter J. Stuckey, Anthony Wirth
BMCBI
2007
233views more  BMCBI 2007»
13 years 7 months ago
160-fold acceleration of the Smith-Waterman algorithm using a field programmable gate array (FPGA)
Background: To infer homology and subsequently gene function, the Smith-Waterman (SW) algorithm is used to find the optimal local alignment between two sequences. When searching s...
Isaac T. S. Li, Warren Shum, Kevin Truong
BMCBI
2007
146views more  BMCBI 2007»
13 years 7 months ago
PubMed related articles: a probabilistic topic-based model for content similarity
Background: We present a probabilistic topic-based model for content similarity called pmra that underlies the related article search feature in PubMed. Whether or not a document ...
Jimmy J. Lin, W. John Wilbur
BMCBI
2008
127views more  BMCBI 2008»
13 years 7 months ago
MetaMine - A tool to detect and analyse gene patterns in their environmental context
Background: Modern sequencing technologies allow rapid sequencing and bioinformatic analysis of genomes and metagenomes. With every new sequencing project a vast number of new pro...
Uta Bohnebeck, Thierry Lombardot, Renzo Kottmann, ...