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» Improving gene set analysis of microarray data by SAM-GS
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BMCBI
2008
106views more  BMCBI 2008»
13 years 7 months ago
SpliceCenter: A suite of web-based bioinformatic applications for evaluating the impact of alternative splicing on RT-PCR, RNAi,
Background: Over 60% of protein-coding genes in vertebrates express mRNAs that undergo alternative splicing. The resulting collection of transcript isoforms poses significant chal...
Michael C. Ryan, Barry Zeeberg, Natasha J. Caplen,...
BMCBI
2007
146views more  BMCBI 2007»
13 years 7 months ago
Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data
Background: Transcriptional modules (TM) consist of groups of co-regulated genes and transcription factors (TF) regulating their expression. Two high-throughput (HT) experimental ...
Xiangdong Liu, Walter J. Jessen, Siva Sivaganesan,...
BMCBI
2005
153views more  BMCBI 2005»
13 years 7 months ago
A comparative review of estimates of the proportion unchanged genes and the false discovery rate
Background: In the analysis of microarray data one generally produces a vector of p-values that for each gene give the likelihood of obtaining equally strong evidence of change by...
Per Broberg
BMCBI
2006
108views more  BMCBI 2006»
13 years 7 months ago
Probe set algorithms: is there a rational best bet?
Affymetrix microarrays have become a standard experimental platform for studies of mRNA expression profiling. Their success is due, in part, to the multiple oligonucleotide featur...
Jinwook Seo, Eric P. Hoffman
BMCBI
2008
112views more  BMCBI 2008»
13 years 7 months ago
Normalization for triple-target microarray experiments
Background: Most microarray studies are made using labelling with one or two dyes which allows the hybridization of one or two samples on the same slide. In such experiments, the ...
Marie-Laure Martin-Magniette, Julie Aubert, Avner ...