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BMCBI
2007
147views more  BMCBI 2007»
13 years 7 months ago
Improved residue contact prediction using support vector machines and a large feature set
Background: Predicting protein residue-residue contacts is an important 2D prediction task. It is useful for ab initio structure prediction and understanding protein folding. In s...
Jianlin Cheng, Pierre Baldi
BMCBI
2008
138views more  BMCBI 2008»
13 years 7 months ago
Using neural networks and evolutionary information in decoy discrimination for protein tertiary structure prediction
Background: We present a novel method of protein fold decoy discrimination using machine learning, more specifically using neural networks. Here, decoy discrimination is represent...
Ching-Wai Tan, David T. Jones
NAR
2008
152views more  NAR 2008»
13 years 7 months ago
PROMALS3D web server for accurate multiple protein sequence and structure alignments
Multiple sequence alignments are essential in computational sequence and structural analysis, with applications in homology detection, structure modeling, function prediction and ...
Jimin Pei, Ming Tang, Nick V. Grishin
BMCBI
2007
107views more  BMCBI 2007»
13 years 7 months ago
Prediction of potential drug targets based on simple sequence properties
Background: During the past decades, research and development in drug discovery have attracted much attention and efforts. However, only 324 drug targets are known for clinical dr...
Qingliang Li, Luhua Lai
BMCBI
2008
142views more  BMCBI 2008»
13 years 7 months ago
Strategies for measuring evolutionary conservation of RNA secondary structures
Background: Evolutionary conservation of RNA secondary structure is a typical feature of many functional non-coding RNAs. Since almost all of the available methods used for predic...
Andreas R. Gruber, Stephan H. F. Bernhart, Ivo L. ...