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AINA
2008
IEEE
14 years 3 months ago
Introducing Variable Gap Penalties into Three-Sequence Alignment for Protein Sequences
The common-use gap penalty strategies, constant penalty and affine gap penalty, have been adopted in the traditional three-sequence alignment algorithm which considers the inserti...
Che-Lun Hung, Chun-Yuan Lin, Yeh-Ching Chung, Chua...
BMCBI
2005
306views more  BMCBI 2005»
13 years 8 months ago
A method for aligning RNA secondary structures and its application to RNA motif detection
Background: Alignment of RNA secondary structures is important in studying functional RNA motifs. In recent years, much progress has been made in RNA motif finding and structure a...
Jianghui Liu, Jason Tsong-Li Wang, Jun Hu, Bin Tia...
KDD
2002
ACM
104views Data Mining» more  KDD 2002»
14 years 9 months ago
Generalization Methods in Bioinformatics
Protein secondary structure prediction and high-throughput drug screen data mining are two important applications in bioinformatics. The data is represented in sparse feature spac...
Steven Eschrich, Nitesh V. Chawla, Lawrence O. Hal...
BMCBI
2008
114views more  BMCBI 2008»
13 years 9 months ago
Combining classifiers for improved classification of proteins from sequence or structure
Background: Predicting a protein's structural or functional class from its amino acid sequence or structure is a fundamental problem in computational biology. Recently, there...
Iain Melvin, Jason Weston, Christina S. Leslie, Wi...
BMCBI
2007
156views more  BMCBI 2007»
13 years 9 months ago
Accuracy of structure-based sequence alignment of automatic methods
Background: Accurate sequence alignments are essential for homology searches and for building three-dimensional structural models of proteins. Since structure is better conserved ...
Changhoon Kim, Byungkook Lee