The common-use gap penalty strategies, constant penalty and affine gap penalty, have been adopted in the traditional three-sequence alignment algorithm which considers the inserti...
Background: Alignment of RNA secondary structures is important in studying functional RNA motifs. In recent years, much progress has been made in RNA motif finding and structure a...
Jianghui Liu, Jason Tsong-Li Wang, Jun Hu, Bin Tia...
Protein secondary structure prediction and high-throughput drug screen data mining are two important applications in bioinformatics. The data is represented in sparse feature spac...
Steven Eschrich, Nitesh V. Chawla, Lawrence O. Hal...
Background: Predicting a protein's structural or functional class from its amino acid sequence or structure is a fundamental problem in computational biology. Recently, there...
Iain Melvin, Jason Weston, Christina S. Leslie, Wi...
Background: Accurate sequence alignments are essential for homology searches and for building three-dimensional structural models of proteins. Since structure is better conserved ...