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» Incremental Signaling Pathway Modeling by Data Integration
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IJON
2006
123views more  IJON 2006»
13 years 6 months ago
A novel approach to model neuronal signal transduction using stochastic differential equations
We introduce a new approach to model the behavior of neuronal signal transduction networks using stochastic differential equations. We present first a mathematical formulation for...
Tiina Manninen, Marja-Leena Linne, Keijo Ruohonen
INCDM
2010
Springer
204views Data Mining» more  INCDM 2010»
13 years 10 months ago
Combining Business Process and Data Discovery Techniques for Analyzing and Improving Integrated Care Pathways
Hospitals increasingly use process models for structuring their care processes. Activities performed to patients are logged to a database but these data are rarely used for managin...
Jonas Poelmans, Guido Dedene, Gerda Verheyden, Her...
BMCBI
2007
123views more  BMCBI 2007»
13 years 6 months ago
Heritable clustering and pathway discovery in breast cancer integrating epigenetic and phenotypic data
Background: In order to recapitulate tumor progression pathways using epigenetic data, we developed novel clustering and pathway reconstruction algorithms, collectively referred t...
Zailong Wang, Pearlly Yan, Dustin P. Potter, Chari...
BMCBI
2010
150views more  BMCBI 2010»
13 years 6 months ago
Systematic calibration of a cell signaling network model
Background: Mathematical modeling is being applied to increasingly complex biological systems and datasets; however, the process of analyzing and calibrating against experimental ...
Kyoung Ae Kim, Sabrina L. Spencer, John G. Albeck,...
BIODATAMINING
2008
140views more  BIODATAMINING 2008»
13 years 6 months ago
Modeling gene-by-environment interaction in comorbid depression with alcohol use disorders via an integrated bioinformatics appr
Background: Comorbidity of Major Depressive Disorder (depression) and Alcohol Use Disorders (AUD) is well documented. Depression, AUD, and the comorbidity of depression with AUD s...
Richard C. McEachin, Benjamin J. Keller, Erika F. ...