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EVOW
2004
Springer
14 years 2 months ago
Iteratively Inferring Gene Regulatory Networks with Virtual Knockout Experiments
Abstract. In this paper we address the problem of finding gene regulatory networks from experimental DNA microarray data. We introduce enhancements to an Evolutionary Algorithm op...
Christian Spieth, Felix Streichert, Nora Speer, An...
BMCBI
2005
98views more  BMCBI 2005»
13 years 8 months ago
The effects of normalization on the correlation structure of microarray data
Background: Stochastic dependence between gene expression levels in microarray data is of critical importance for the methods of statistical inference that resort to pooling test-...
Xing Qiu, Andrew I. Brooks, Lev Klebanov, Andrei Y...
BMCBI
2008
138views more  BMCBI 2008»
13 years 8 months ago
M-BISON: Microarray-based integration of data sources using networks
Background: The accurate detection of differentially expressed (DE) genes has become a central task in microarray analysis. Unfortunately, the noise level and experimental variabi...
Bernie J. Daigle Jr., Russ B. Altman
JCB
2007
130views more  JCB 2007»
13 years 8 months ago
Bayesian Inference of MicroRNA Targets from Sequence and Expression Data
MicroRNAs (miRNAs) regulate a large proportion of mammalian genes by hybridizing to targeted messenger RNAs (mRNAs) and down-regulating their translation into protein. Although mu...
Jim C. Huang, Quaid Morris, Brendan J. Frey
BMCBI
2008
138views more  BMCBI 2008»
13 years 8 months ago
Novel implementation of conditional co-regulation by graph theory to derive co-expressed genes from microarray data
Background: Most existing transcriptional databases like Comprehensive Systems-Biology Database (CSB.DB) and Arabidopsis Microarray Database and Analysis Toolbox (GENEVESTIGATOR) ...
Arun Rawat, Georg J. Seifert, Youping Deng