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» Inferring differentiation pathways from gene expression
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GCB
2010
Springer
204views Biometrics» more  GCB 2010»
13 years 6 months ago
Learning Pathway-based Decision Rules to Classify Microarray Cancer Samples
: Despite recent advances in DNA chip technology current microarray gene expression studies are still affected by high noise levels, small sample sizes and large numbers of uninfor...
Enrico Glaab, Jonathan M. Garibaldi, Natalio Krasn...
BMCBI
2010
106views more  BMCBI 2010»
13 years 8 months ago
A computational evaluation of over-representation of regulatory motifs in the promoter regions of differentially expressed genes
Background: Observed co-expression of a group of genes is frequently attributed to co-regulation by shared transcription factors. This assumption has led to the hypothesis that pr...
Guofeng Meng, Axel Mosig, Martin Vingron
BIOCOMP
2006
13 years 10 months ago
Dynamic Bayesian Network (DBN) with Structure Expectation Maximization (SEM) for Modeling of Gene Network from Time Series Gene
Exploring gene regulatory network is a key topic in molecular biology. In this paper, we present a new dynamic Bayesian network (DBN) framework embedded with structural expectatio...
Yu Zhang, Zhidong Deng, Hongshan Jiang, Peifa Jia
ICIC
2009
Springer
13 years 6 months ago
Inference of Differential Equation Models by Multi Expression Programming for Gene Regulatory Networks
This paper presents an evolutionary method for identifying the gene regulatory network from the observed time series data of gene expression using a system of ordinary differential...
Bin Yang, Yuehui Chen, Qingfang Meng
BMCBI
2007
114views more  BMCBI 2007»
13 years 8 months ago
Large scale statistical inference of signaling pathways from RNAi and microarray data
Background: The advent of RNA interference techniques enables the selective silencing of biologically interesting genes in an efficient way. In combination with DNA microarray tec...
Holger Fröhlich, Mark Fellmann, Holger Sü...