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BMCBI
2010
13 years 5 months ago
2010
Background: We suggest a new type of modeling approach for the coarse grained, particle-based spatial simulation of combinatorially complex chemical reaction systems. In our appro...
BMCBI
2010
13 years 5 months ago
2010
Background: The functional and structural characterisation of enzymes that belong to microbial metabolic pathways is very important for structure-based drug design. The main inter...
BMCBI
2010
13 years 5 months ago
2010
Background: The dynamic motions of many proteins are central to their function. It therefore follows that the dynamic requirements of a protein are evolutionary constrained. In or...
BMCBI
2010
13 years 5 months ago
2010
Background: Ever since the ground-breaking work of Anfinsen et al. in which a denatured protein was found to refold to its native state, it has been frequently stated by the prote...
BMCBI
2010
13 years 5 months ago
2010
Background: The post-genomic era has brought new challenges regarding the understanding of the organization and function of the human genome. Many of these challenges are centered...