ProbFAST: Probabilistic Functional Analysis System Tool

Background: The post-genomic era has brought new challenges regarding the understanding of the organization and function of the human genome. Many of these challenges are centered on the meaning of differential gene regulation under distinct biological conditions and can be performed by analyzing the Multiple Differential Expression (MDE) of genes associated with normal and abnormal biological processes. Currently MDE analyses are limited to usual methods of differential expression initially designed for paired analysis. Results: We proposed a web platform named ProbFAST for MDE analysis which uses Bayesian inference to identify key genes that are intuitively prioritized by means of probabilities. A simulated study revealed that our method gives a better performance when compared to other approaches and when applied to public expression data, we demonstrated its flexibility to obtain relevant genes biologically associated with normal and abnormal biological processes. Conclusions: Pro...

• Type: Journal
• Year: 2010
• Where: BMCBI
• Authors: Israel T. da Silva, Ricardo Z. N. Vêncio, Thiago Y. K. Oliveira, Greice A. Molfetta, Wilson A. Silva Jr.
• Keywords: Abnormal Biological Processes, BMCBI 2010, Business, Gene Expression, MDE Analysis