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BMCBI
2007
157views more  BMCBI 2007»
13 years 7 months ago
Constructing gene co-expression networks and predicting functions of unknown genes by random matrix theory
Background: Large-scale sequencing of entire genomes has ushered in a new age in biology. One of the next grand challenges is to dissect the cellular networks consisting of many i...
Feng Luo, Yunfeng Yang, Jianxin Zhong, Haichun Gao...
BMCBI
2006
98views more  BMCBI 2006»
13 years 7 months ago
In search of functional association from time-series microarray data based on the change trend and level of gene expression
Background: The increasing availability of time-series expression data opens up new possibilities to study functional linkages of genes. Present methods used to infer functional l...
Feng He, An-Ping Zeng
BMCBI
2011
12 years 11 months ago
Reconstructing genome-wide regulatory network of E. coli using transcriptome data and predicted transcription factor activities
Background: Gene regulatory networks play essential roles in living organisms to control growth, keep internal metabolism running and respond to external environmental changes. Un...
Yao Fu, Laura R. Jarboe, Julie A. Dickerson
BMCBI
2010
114views more  BMCBI 2010»
13 years 7 months ago
An integrative modular approach to systematically predict gene-phenotype associations
Background: Complex human diseases are often caused by multiple mutations, each of which contributes only a minor effect to the disease phenotype. To study the basis for these com...
Michael R. Mehan, Juan Nunez-Iglesias, Chao Dai, M...
BMCBI
2005
84views more  BMCBI 2005»
13 years 7 months ago
A method of precise mRNA/DNA homology-based gene structure prediction
Background: Accurate and automatic gene finding and structural prediction is a common problem in bioinformatics, and applications need to be capable of handling non-canonical spli...
Alexander G. Churbanov, Mark Pauley, Daniel Quest,...