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BMCBI
2010
142views more  BMCBI 2010»
13 years 7 months ago
Discover Protein Complexes in Protein-Protein Interaction Networks Using Parametric Local Modularity
Background: Recent advances in proteomic technologies have enabled us to create detailed protein-protein interaction maps in multiple species and in both normal and diseased cells...
Jongkwang Kim, Kai Tan
RECOMB
2006
Springer
14 years 8 months ago
De Novo Signaling Pathway Predictions Based on Protein-Protein Interaction, Targeted Therapy and Protein Microarray Analysis
Abstract. Mapping intra-cellular signaling networks is a critical step in developing an understanding of and treatments for many devastating diseases. The predominant ways of disco...
Derek A. Ruths, Jen-Te Tseng, Luay Nakhleh, Prahla...
TCAD
2010
133views more  TCAD 2010»
13 years 2 months ago
Defect-Tolerant Design and Optimization of a Digital Microfluidic Biochip for Protein Crystallization
Protein crystallization is a commonly used technique for protein analysis and subsequent drug design. It predicts the 3-D arrangement of the constituent amino acids, which in turn ...
Tao Xu, Krishnendu Chakrabarty, Vamsee K. Pamula
BMCBI
2010
156views more  BMCBI 2010»
13 years 7 months ago
Protein complex prediction via verifying and reconstructing the topology of domain-domain interactions
Background: High-throughput methods for detecting protein-protein interactions enable us to obtain large interaction networks, and also allow us to computationally identify the as...
Yosuke Ozawa, Rintaro Saito, Shigeo Fujimori, Hisa...
BMCBI
2008
168views more  BMCBI 2008»
13 years 7 months ago
Predicting protein folding pathways at the mesoscopic level based on native interactions between secondary structure elements
Background: Since experimental determination of protein folding pathways remains difficult, computational techniques are often used to simulate protein folding. Most current techn...
Qingwu Yang, Sing-Hoi Sze