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BMCBI
2008
102views more  BMCBI 2008»
13 years 10 months ago
Improving protein function prediction methods with integrated literature data
Background: Determining the function of uncharacterized proteins is a major challenge in the post-genomic era due to the problem's complexity and scale. Identifying a protein...
Aaron Gabow, Sonia M. Leach, William A. Baumgartne...
BMCBI
2006
150views more  BMCBI 2006»
13 years 10 months ago
Protein structure similarity from principle component correlation analysis
Background: Owing to rapid expansion of protein structure databases in recent years, methods of structure comparison are becoming increasingly effective and important in revealing...
Xiaobo Zhou, James Chou, Stephen T. C. Wong
BMCBI
2007
115views more  BMCBI 2007»
13 years 10 months ago
Recognizing protein-protein interfaces with empirical potentials and reduced amino acid alphabets
Background: In structural genomics, an important goal is the detection and classification of protein–protein interactions, given the structures of the interacting partners. We h...
Guillaume Launay, Raul Mendez, Shoshana J. Wodak, ...
BMCBI
2010
83views more  BMCBI 2010»
13 years 10 months ago
An effective approach for generating a three-Cys2His2 zinc-finger-DNA complex model by docking
Background: Determination of protein-DNA complex structures with both NMR and X-ray crystallography remains challenging in many cases. High Ambiguity-Driven DOCKing (HADDOCK) is a...
Chun-Chi Chou, M. Rajasekaran, Chinpan Chen
RECOMB
2005
Springer
14 years 10 months ago
Causal Inference of Regulator-Target Pairs by Gene Mapping of Expression Phenotypes
Background: Correlations between polymorphic markers and observed phenotypes provide the basis for mapping traits in quantitative genetics. When the phenotype is gene expression, ...
David Kulp, Manjunatha Jagalur