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BMCBI
2010
132views more  BMCBI 2010»
13 years 7 months ago
Error margin analysis for feature gene extraction
Background: Feature gene extraction is a fundamental issue in microarray-based biomarker discovery. It is normally treated as an optimization problem of finding the best predictiv...
Chi Kin Chow, Hai Long Zhu, Jessica Lacy, Winston ...
BMCBI
2006
123views more  BMCBI 2006»
13 years 7 months ago
Characterizing disease states from topological properties of transcriptional regulatory networks
Background: High throughput gene expression experiments yield large amounts of data that can augment our understanding of disease processes, in addition to classifying samples. He...
David Tuck, Harriet Kluger, Yuval Kluger
BIBM
2009
IEEE
192views Bioinformatics» more  BIBM 2009»
14 years 2 months ago
A Multi-task Feature Selection Filter for Microarray Classification
A major challenge in microarray classification and biomarker discovery is dealing with small-sample high-dimensional data where the number of genes used as features is typically o...
Liang Lan, Slobodan Vucetic
JCB
2002
70views more  JCB 2002»
13 years 7 months ago
Strong Feature Sets from Small Samples
For small samples, classi er design algorithms typically suffer from over tting. Given a set of features, a classi er must be designed and its error estimated. For small samples, ...
Seungchan Kim, Edward R. Dougherty, Junior Barrera...
ECAI
2004
Springer
13 years 11 months ago
Avoiding Data Overfitting in Scientific Discovery: Experiments in Functional Genomics
Functional genomics is a typical scientific discovery domain characterized by a very large number of attributes (genes) relative to the number of examples (observations). The dang...
Dragan Gamberger, Nada Lavrac