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» Large scale hierarchical clustering of protein sequences
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BIBM
2008
IEEE
170views Bioinformatics» more  BIBM 2008»
14 years 3 months ago
Protein Sequence Motif Super-Rule-Tree (SRT) Structure Constructed by Hybrid Hierarchical K-Means Clustering Algorithm
— Protein sequence motifs information is crucial to the analysis of biologically significant regions. The conserved regions have the potential to determine the role of the protei...
Bernard Chen, Jieyue He, Stephen Pellicer, Yi Pan
BIBE
2003
IEEE
133views Bioinformatics» more  BIBE 2003»
14 years 1 months ago
A Computational Pipeline for Protein Structure Prediction and Analysis at Genome Scale
The tertiary (3D) structure of a protein contains the essential information for understanding the biological function of the protein at the molecular and cellular levels. Traditio...
Manesh J. Shah, Sergei Passovets, Dongsup Kim, Kyl...
BMCBI
2007
202views more  BMCBI 2007»
13 years 8 months ago
ProtNet: a tool for stochastic simulations of protein interaction networks dynamics
Background: Protein interactions support cell organization and mediate its response to any specific stimulus. Recent technological advances have produced large data-sets that aim ...
Massimo Bernaschi, Filippo Castiglione, Alessandra...
AAAI
2008
13 years 11 months ago
Visualization of Large-Scale Weighted Clustered Graph: A Genetic Approach
In this paper, a bottom-up hierarchical genetic algorithm is proposed to visualize clustered data into a planar graph. To achieve global optimization by accelerating local optimiz...
Jiayu Zhou, Youfang Lin, Xi Wang
BMCBI
2010
156views more  BMCBI 2010»
13 years 8 months ago
Mathematical model for empirically optimizing large scale production of soluble protein domains
Background: Efficient dissection of large proteins into their structural domains is critical for high throughput proteome analysis. So far, no study has focused on mathematically ...
Eisuke Chikayama, Atsushi Kurotani, Takanori Tanak...