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BMCBI
2006
138views more  BMCBI 2006»
13 years 7 months ago
Determination of strongly overlapping signaling activity from microarray data
Background: As numerous diseases involve errors in signal transduction, modern therapeutics often target proteins involved in cellular signaling. Interpretation of the activity of...
Ghislain Bidaut, Karsten Suhre, Jean-Michel Claver...
BMCBI
2006
152views more  BMCBI 2006»
13 years 7 months ago
Amplification of the Gene Ontology annotation of Affymetrix probe sets
Background: The annotations of Affymetrix DNA microarray probe sets with Gene Ontology terms are carefully selected for correctness. This results in very accurate but incomplete a...
Enrique M. Muro, Carolina Perez-Iratxeta, Miguel A...
JIB
2006
106views more  JIB 2006»
13 years 7 months ago
A structural keystone for drug design
3D-structures of proteins and potential ligands are the cornerstones of rational drug design. The first brick to build upon is selecting a protein target and finding out whether b...
Kristian Rother, Mathias Dunkel, Elke Michalsky, S...
BMCBI
2005
124views more  BMCBI 2005»
13 years 7 months ago
Internet-based profiler system as integrative framework to support translational research
Background: Translational research requires taking basic science observations and developing them into clinically useful tests and therapeutics. We have developed a process to dev...
Robert Kim, Francesca Demichelis, Jeffery Tang, Al...
BMCBI
2005
151views more  BMCBI 2005»
13 years 7 months ago
ProMiner: rule-based protein and gene entity recognition
Background: Identification of gene and protein names in biomedical text is a challenging task as the corresponding nomenclature has evolved over time. This has led to multiple syn...
Daniel Hanisch, Katrin Fundel, Heinz-Theodor Mevis...