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BMCBI
2010
105views more  BMCBI 2010»
13 years 10 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
BMCBI
2010
232views more  BMCBI 2010»
13 years 10 months ago
LucidDraw: Efficiently visualizing complex biochemical networks within MATLAB
Background: Biochemical networks play an essential role in systems biology. Rapidly growing network data and e research activities call for convenient visualization tools to aid i...
Sheng He, Juan Mei, Guiyang Shi, Zhengxiang Wang, ...
BMCBI
2008
110views more  BMCBI 2008»
13 years 10 months ago
Determining significance of pairwise co-occurrences of events in bursty sequences
Background: Event sequences where different types of events often occur close together arise, e.g., when studying potential transcription factor binding sites (TFBS, events) of ce...
Niina Haiminen, Heikki Mannila, Evimaria Terzi
BMCBI
2007
181views more  BMCBI 2007»
13 years 10 months ago
ASMPKS: an analysis system for modular polyketide synthases
Background: Polyketides are secondary metabolites of microorganisms with diverse biological activities, including pharmacological functions such as antibiotic, antitumor and agroc...
Hongseok Tae, Eun-Bae Kong, Kiejung Park
BMCBI
2008
200views more  BMCBI 2008»
13 years 10 months ago
Defining functional distances over Gene Ontology
Background: A fundamental problem when trying to define the functional relationships between proteins is the difficulty in quantifying functional similarities, even when well-stru...
Angela del Pozo, Florencio Pazos, Alfonso Valencia
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