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» Massively-Parallel Simulation of Biochemical Systems
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TCAD
2010
118views more  TCAD 2010»
13 years 1 months ago
Design Tools for Digital Microfluidic Biochips: Toward Functional Diversification and More Than Moore
Abstract--Microfluidics-based biochips enable the precise control of nanoliter volumes of biochemical samples and reagents. They combine electronics with biology, and they integrat...
Krishnendu Chakrabarty, Richard B. Fair, Jun Zeng
BMCBI
2007
173views more  BMCBI 2007»
13 years 7 months ago
Predicting state transitions in the transcriptome and metabolome using a linear dynamical system model
Background: Modelling of time series data should not be an approximation of input data profiles, but rather be able to detect and evaluate dynamical changes in the time series dat...
Ryoko Morioka, Shigehiko Kanaya, Masami Y. Hirai, ...
VLSID
2007
IEEE
131views VLSI» more  VLSID 2007»
14 years 7 months ago
Defect-Aware Synthesis of Droplet-Based Microfluidic Biochips
Recent advances in microfluidics technology have led to the emergence of miniaturized biochip devices for biochemical analysis. A promising category of microfluidic biochips relie...
Tao Xu, Krishnendu Chakrabarty, Fei Su
RECOMB
2008
Springer
14 years 7 months ago
High-Resolution Modeling of Cellular Signaling Networks
A central challenge in systems biology is the reconstruction of biological networks from high-throughput data sets. A particularly difficult case of this is the inference of dynami...
Michael Baym, Chris Bakal, Norbert Perrimon, Bonni...
BMCBI
2010
123views more  BMCBI 2010»
13 years 7 months ago
Computationally efficient flux variability analysis
Background: Flux variability analysis is often used to determine robustness of metabolic models in various simulation conditions. However, its use has been somehow limited by the ...
Steinn Gudmundsson, Ines Thiele