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BMCBI
2010
101views more  BMCBI 2010»
13 years 7 months ago
Hidden Markov model speed heuristic and iterative HMM search procedure
Background: Profile hidden Markov models (profile-HMMs) are sensitive tools for remote protein homology detection, but the main scoring algorithms, Viterbi or Forward, require con...
L. Steven Johnson, Sean R. Eddy, Elon Portugaly
BMCBI
2008
128views more  BMCBI 2008»
13 years 7 months ago
SIGffRid: A tool to search for sigma factor binding sites in bacterial genomes using comparative approach and biologically drive
Background: Many programs have been developed to identify transcription factor binding sites. However, most of them are not able to infer two-word motifs with variable spacer leng...
Fabrice Touzain, Sophie Schbath, Isabelle Debled-R...
BMCBI
2007
226views more  BMCBI 2007»
13 years 7 months ago
MiRFinder: an improved approach and software implementation for genome-wide fast microRNA precursor scans
Background: MicroRNAs (miRNAs) are recognized as one of the most important families of noncoding RNAs that serve as important sequence-specific post-transcriptional regulators of ...
Ting-Hua Huang, Bin Fan, Max F. Rothschild, Zhi-Li...
BMCBI
2008
88views more  BMCBI 2008»
13 years 7 months ago
Large-scale identification of polymorphic microsatellites using an in silico approach
Background: Simple Sequence Repeat (SSR) or microsatellite markers are valuable for genetic research. Experimental methods to develop SSR markers are laborious, time consuming and...
Jifeng Tang, Samantha J. Baldwin, Jeanne M. E. Jac...
BMCBI
2008
141views more  BMCBI 2008»
13 years 7 months ago
MiRTif: a support vector machine-based microRNA target interaction filter
Background: MicroRNAs (miRNAs) are a set of small non-coding RNAs serving as important negative gene regulators. In animals, miRNAs turn down protein translation by binding to the...
Yuchen Yang, Yu-Ping Wang, Kuo-Bin Li
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