Background: Signal transduction is one of the most important biological processes by which cells convert an external signal into a response. Novel computational approaches to mapp...
Background: Epistatic miniarray profiling (E-MAPs) is a high-throughput approach capable of quantifying aggravating or alleviating genetic interactions between gene pairs. The dat...
Background: Intracellular signal transduction is achieved by networks of proteins and small molecules that transmit information from the cell surface to the nucleus, where they ul...
Martin Steffen, Allegra Petti, John Aach, Patrik D...
In this paper, we introduce a novel objective function for the hierarchical clustering of data from distance matrices, a very relevant task in Bioinformatics. To test the robustnes...
Pritha Mahata, Wagner Costa, Carlos Cotta, Pablo M...
Background: In high-dimensional data analysis such as differential gene expression analysis, people often use filtering methods like fold-change or variance filters in an attempt ...