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WSC
1997
13 years 9 months ago
Covalidation of Dissimilarly Structured Models
A methodology is presented which allows comparison between models under different modeling paradigms. Consider the following situation: Two models have been constructed to study d...
Samuel A. Wright, Kenneth W. Bauer Jr.
USENIX
1994
13 years 9 months ago
TreadMarks: Distributed Shared Memory on Standard Workstations and Operating Systems
TreadMarks is a distributed shared memory DSM system for standard Unix systems such as SunOS and Ultrix. This paper presents a performance evaluation of TreadMarks running on Ultr...
Peter J. Keleher, Alan L. Cox, Sandhya Dwarkadas, ...
ESA
2010
Springer
246views Algorithms» more  ESA 2010»
13 years 8 months ago
Estimating the Average of a Lipschitz-Continuous Function from One Sample
We study the problem of estimating the average of a Lipschitz continuous function f defined over a metric space, by querying f at only a single point. More specifically, we explore...
Abhimanyu Das, David Kempe
BMCBI
2010
116views more  BMCBI 2010»
13 years 7 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
BMCBI
2007
102views more  BMCBI 2007»
13 years 7 months ago
FlexOracle: predicting flexible hinges by identification of stable domains
Background: Protein motions play an essential role in catalysis and protein-ligand interactions, but are difficult to observe directly. A substantial fraction of protein motions i...
Samuel Flores, Mark Gerstein
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