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» Mining Residue Contacts in Proteins
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BMCBI
2010
86views more  BMCBI 2010»
13 years 7 months ago
Protein binding hot spots and the residue-residue pairing preference: a water exclusion perspective
Background: A protein binding hot spot is a small cluster of residues tightly packed at the center of the interface between two interacting proteins. Though a hot spot constitutes...
Qian Liu, Jinyan Li
GCB
2000
Springer
99views Biometrics» more  GCB 2000»
13 years 11 months ago
Structure Motif Discovery and Mining the PDB
We describe an algorithm for the automatic discovery of recurring patterns in protein structures. The patterns consist of individual residues having a defined order along the prote...
Inge Jonassen, Ingvar Eidhammer, Darrell Conklin, ...
CPM
2004
Springer
168views Combinatorics» more  CPM 2004»
14 years 23 days ago
The Protein Sequence Design Problem in Canonical Model on 2D and 3D Lattices
In this paper we investigate the protein sequence design (PSD) problem (also known as the inverse protein folding problem) under the Canonical model 4 on 2D and 3D lattices [12, 25...
Piotr Berman, Bhaskar DasGupta, Dhruv Mubayi, Robe...
BMCBI
2008
145views more  BMCBI 2008»
13 years 7 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...
BMCBI
2007
151views more  BMCBI 2007»
13 years 7 months ago
Identification of hot regions in protein-protein interactions by sequential pattern mining
Background: Identification of protein interacting sites is an important task in computational molecular biology. As more and more protein sequences are deposited without available...
Chen-Ming Hsu, Chien-Yu Chen, Baw-Jhiune Liu, Chih...