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BMCBI
2005
169views more  BMCBI 2005»
13 years 7 months ago
An adaptive method for cDNA microarray normalization
Background: Normalization is a critical step in analysis of gene expression profiles. For duallabeled arrays, global normalization assumes that the majority of the genes on the ar...
Yingdong Zhao, Ming-Chung Li, Richard Simon
BMCBI
2008
115views more  BMCBI 2008»
13 years 7 months ago
Principal components analysis based methodology to identify differentially expressed genes in time-course microarray data
Background: Time-course microarray experiments are being increasingly used to characterize dynamic biological processes. In these experiments, the goal is to identify genes differ...
Sudhakar Jonnalagadda, Rajagopalan Srinivasan
BMCBI
2006
153views more  BMCBI 2006»
13 years 7 months ago
Intensity-based hierarchical Bayes method improves testing for differentially expressed genes in microarray experiments
Background: The small sample sizes often used for microarray experiments result in poor estimates of variance if each gene is considered independently. Yet accurately estimating v...
Maureen A. Sartor, Craig R. Tomlinson, Scott C. We...
BMEI
2009
IEEE
13 years 8 months ago
An Improved Probabilistic Model for Finding Differential Gene Expression
Abstract--Finding differentially expressed genes is a fundamental objective of a microarray experiment. Recently proposed method, PPLR, considers the probe-level measurement error ...
Li Zhang, Xuejun Liu
BMCBI
2007
159views more  BMCBI 2007»
13 years 7 months ago
Detecting differential expression in microarray data: comparison of optimal procedures
Background: Many procedures for finding differentially expressed genes in microarray data are based on classical or modified t-statistics. Due to multiple testing considerations, ...
Elena Perelman, Alexander Ploner, Stefano Calza, Y...