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BMCBI
2006
82views more  BMCBI 2006»
13 years 8 months ago
Transcriptomic response to differentiation induction
Background: Microarrays used for gene expression studies yield large amounts of data. The processing of such data typically leads to lists of differentially-regulated genes. A com...
G. W. Patton, Robert M. Stephens, I. A. Sidorov, X...
TNN
2008
105views more  TNN 2008»
13 years 8 months ago
Generalized Linear Discriminant Analysis: A Unified Framework and Efficient Model Selection
Abstract--High-dimensional data are common in many domains, and dimensionality reduction is the key to cope with the curse-of-dimensionality. Linear discriminant analysis (LDA) is ...
Shuiwang Ji, Jieping Ye
BMCBI
2004
117views more  BMCBI 2004»
13 years 8 months ago
Cancer characterization and feature set extraction by discriminative margin clustering
Background: A central challenge in the molecular diagnosis and treatment of cancer is to define a set of molecular features that, taken together, distinguish a given cancer, or ty...
Kamesh Munagala, Robert Tibshirani, Patrick O. Bro...
GECCO
2005
Springer
180views Optimization» more  GECCO 2005»
14 years 2 months ago
Inference of gene regulatory networks using s-system and differential evolution
In this work we present an improved evolutionary method for inferring S-system model of genetic networks from the time series data of gene expression. We employed Differential Ev...
Nasimul Noman, Hitoshi Iba
BIOINFORMATICS
2006
124views more  BIOINFORMATICS 2006»
13 years 8 months ago
Probabilistic inference of transcription factor concentrations and gene-specific regulatory activities
Motivation Quantitative estimation of the regulatory relationship between transcription factors and genes is a fundamental stepping stone when trying to develop models of cellular...
Guido Sanguinetti, Neil D. Lawrence, Magnus Rattra...