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» Modelling Developmental Regulatory Networks
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BMCBI
2007
130views more  BMCBI 2007»
13 years 8 months ago
A model-based optimization framework for the inference of regulatory interactions using time-course DNA microarray expression da
Background: Proteins are the primary regulatory agents of transcription even though mRNA expression data alone, from systems like DNA microarrays, are widely used. In addition, th...
Reuben Thomas, Carlos J. Paredes, Sanjay Mehrotra,...
BMCBI
2008
154views more  BMCBI 2008»
13 years 8 months ago
GeNESiS: gene network evolution simulation software
Background: There has been a lot of interest in recent years focusing on the modeling and simulation of Gene Regulatory Networks (GRNs). However, the evolutionary mechanisms that ...
Anton Kratz, Masaru Tomita, Arun Krishnan
TSP
2008
132views more  TSP 2008»
13 years 8 months ago
Robust Intervention in Probabilistic Boolean Networks
Probabilistic Boolean networks (PBNs) have been recently introduced as a paradigm for modeling genetic regulatory networks. One of the objectives of PBN modeling is to use the netw...
Ranadip Pal, Aniruddha Datta, Edward R. Dougherty
BMCBI
2010
160views more  BMCBI 2010»
13 years 8 months ago
Quantitative model for inferring dynamic regulation of the tumour suppressor gene p53
Background: The availability of various "omics" datasets creates a prospect of performing the study of genomewide genetic regulatory networks. However, one of the major ...
Junbai Wang, Tianhai Tian
BMCBI
2007
137views more  BMCBI 2007»
13 years 8 months ago
PlnTFDB: an integrative plant transcription factor database
Background: Transcription factors (TFs) are key regulatory proteins that enhance or repress the transcriptional rate of their target genes by binding to specific promoter regions ...
Diego Mauricio Riaño-Pachón, Sloboda...