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» Modelling Developmental Regulatory Networks
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ESANN
2007
13 years 9 months ago
Transition from initialization to working stage in biologically realistic networks
Natural cortical neurons form functional networks through a complex set of developmental steps. A key process in early development is the transition of the spontaneous network dyna...
Andreas Herzog, Karsten Kube, Bernd Michaelis, Ana...
BMCBI
2005
178views more  BMCBI 2005»
13 years 8 months ago
A quantization method based on threshold optimization for microarray short time series
Background: Reconstructing regulatory networks from gene expression profiles is a challenging problem of functional genomics. In microarray studies the number of samples is often ...
Barbara Di Camillo, Fatima Sanchez-Cabo, Gianna To...
GECCO
2006
Springer
220views Optimization» more  GECCO 2006»
13 years 11 months ago
Comparing evolutionary algorithms on the problem of network inference
In this paper, we address the problem of finding gene regulatory networks from experimental DNA microarray data. We focus on the evaluation of the performance of different evoluti...
Christian Spieth, Rene Worzischek, Felix Streicher...
EVOW
2007
Springer
14 years 2 months ago
Modeling the Shoot Apical Meristem in A. thaliana : Parameter Estimation for Spatial Pattern Formation
Understanding the self-regulatory mechanisms controlling the spatial and temporal structure of multicellular organisms represents one of the major challenges in molecular biology. ...
Tim Hohm, Eckart Zitzler
BMCBI
2007
146views more  BMCBI 2007»
13 years 8 months ago
Bayesian hierarchical model for transcriptional module discovery by jointly modeling gene expression and ChIP-chip data
Background: Transcriptional modules (TM) consist of groups of co-regulated genes and transcription factors (TF) regulating their expression. Two high-throughput (HT) experimental ...
Xiangdong Liu, Walter J. Jessen, Siva Sivaganesan,...