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» Models and Methods in Comparative Genomics
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BMCBI
2005
135views more  BMCBI 2005»
13 years 11 months ago
A robust two-way semi-linear model for normalization of cDNA microarray data
Background: Normalization is a basic step in microarray data analysis. A proper normalization procedure ensures that the intensity ratios provide meaningful measures of relative e...
Deli Wang, Jian Huang, Hehuang Xie, Liliana Manzel...
BIOCOMP
2006
14 years 11 days ago
Reverse Engineering Approach in Molecular Evolution: Simulation and Case Study with Enzyme Proteins
- We developed a method of reverse engineering to compare the behaviour the enzyme proteins with the existing standard concepts. Our work is based on the strong assumption from the...
Sukanya Manna, Cheng-Yuan Liou
BMCBI
2008
113views more  BMCBI 2008»
13 years 11 months ago
Investigating selection on viruses: a statistical alignment approach
Background: Two problems complicate the study of selection in viral genomes: Firstly, the presence of genes in overlapping reading frames implies that selection in one reading fra...
Saskia de Groot, Thomas Mailund, Gerton Lunter, Jo...
BMCBI
2007
148views more  BMCBI 2007»
13 years 11 months ago
Toward the automated generation of genome-scale metabolic networks in the SEED
Background: Current methods for the automated generation of genome-scale metabolic networks focus on genome annotation and preliminary biochemical reaction network assembly, but d...
Matthew DeJongh, Kevin Formsma, Paul Boillot, John...
BMCBI
2008
105views more  BMCBI 2008»
13 years 11 months ago
A gene pattern mining algorithm using interchangeable gene sets for prokaryotes
Background: Mining gene patterns that are common to multiple genomes is an important biological problem, which can lead us to novel biological insights. When family classification...
Meng Hu, Kwangmin Choi, Wei Su, Sun Kim, Jiong Yan...